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TTYtter is a console console Twitter client. It's not an application but a python script that allows you to use Twitter just like any advanced Twitter client, but within a terminal. And it's not just for posting tweets, but has advanced options like any other well-known Twitter desktop client.
Hotot is a lightweight, python-based, desktop twitter client I tried on my Linux Mint 10 GNOME desktop. I found Hotot to include many features you’d expect in a desktop client and a few you may not.
Tumblr is a popular mini-blogging service. Kumblr is a desktop application written in Python (and aimed at KDE users) that provides a simple, but functional interface to post text to your Tumblog.
Twidge is a command-line, full-functional Twitter and identi.ca client. It supports posting updates, retrieving information, and excellent integration with the Unix shell scripting environment via piping and well-formatted output.
Twitter is preparing to launch several impressive new features, including a new streaming API that will give desktop client applications real-time access to the user's message timeline. The new streaming API was announced last week at Twitter's Chirp conference, where it was made available to conference attendees on-site for some preliminary experimentation.